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KMID : 0854720100300020135
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Korean Journal of Asthma, Allergy and Clinical Immunology
2010 Volume.30 No. 2 p.135 ~ p.139
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Pulmonary Thromboembolism Associated with Protein S Deficiency in a Patient with Difficult-to-Control Asthma
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Park Chung-Hwa
Yoon Seung-Bae
Kim Dae-Bum
Lee Han-Hee
Kim Chan-Joon
Kim Jeong-Ho
Ko Hoon-Young
Lee Mi-Jeong
Lee Hwa-Jeong
Kim Seung-Su
Kim Myung-Sook
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Abstract
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Asthma is a chronic multifactorial disease with frequent exacerbations in many patients. Much effort has been made to determine prevalent factors associated with difficult- to-control asthma. Here we report the case of a 57-year-old man who was treated for asthma during the last 4 years at our pulmonology clinic. Recently, the patient experienced severe dyspnea for more than 3 months despite the addition of the leukotriene modifier, theophylline and oral cortic-osteroid. Chest CT scans revealed multifocal areas of pulmonary arterial thrombosis. Doppler ultrasonograms showed multiple deep vein thrombi. The patient was diagnosed of having protein S deficiency and was treated with low molecular weight heparin, followed by oral warfarin. Now, he has no pulmonary arterial thrombosis and has no more asthmatic attack for half a year.
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KEYWORD
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Difficult-to-control asthma, Pulmonary thromboembolism, Deep vein thrombosis, Protein S deficiency
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